FERMT3 Antibody (N-Term) [APR15948G]

FERMT3 Antibody (N-Term) [APR15948G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This FERMT3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 117-151 amino acids of mouse FERMT3.

Cellular Localisation: Cell projection, podosome. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells

Molecular Weight: 75953

Clone: Polyclonal

Gene Name: FERMT3

Gene ID: 83706

Function: Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933) . Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity) . Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460) . Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity) .

Summary: Tissue Location: Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Fermitin family homolog 3, Kindlin-3, MIG2-like protein, Unc-112-related protein 2, FERMT3, KIND3, MIG2B, URP2