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Ferritin polyclonal Antibody | BS90500
- SKU:
- BW-BS90500
- Availability:
- Usually ships in 5 working days
Description
Ferritin polyclonal Antibody | BS90500 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat, zebrafish
Application: WB ICC/IF
Application Range: WB:1:500-1:1,000 ICC:1:50-1:200
Background: Mammalian ferritins consist of 24 subunits made up of two types of polypeptide chains, ferritin heavy chain and ferritin light chain, which each have unique functions. Ferritin heavy chains catalyze the first step in iron storage, the oxidation of Fe (II), whereas ferritin light chains promote the nucleation of ferrihydrite, enabling storage of Fe (III) . The most prominent role of mammalian ferritins is to provide iron-buffering capacity to cells. In addition to iron buffering, heavy chain ferritin is also involved in the regulation of thymidine biosynthesis via increased expression of cytoplasmic serine hydroxymethyltransferase, which is a limiting factor in thymidylate synthesis in MCF-7 cells. Light chain ferritin is involved in cataracts by at least two mechanisms, hereditary hyperferritinemia cataract syndrome, in which light chain ferritin is overexpressed, and oxidative stress, an important factor in the development of ageing-related cataracts. The gene encoding human ferritin heavy chain maps to chromosome 11q13 and the human ferritin light chain gene maps to chromosome 19q13.3-q13.4.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Ferritin polyclonal Antibody detects endogenous levels of Ferritin protein.
Molecular Weight: 21 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Ferritin H subunit, FTH1, Ferritin L subunit, FTL, Cell proliferation-inducing gene 15 protein, Ferritin H subunit, Ferritin heavy chain, Ferritin heavy polypeptide 1, Ferritin L subunit, Ferritin light polypeptide, Ferritin, heavy polypeptide, FRIH, FTH, FTH1, FTL,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: