Description
Fevipiprant is a prostaglandin D2 (PGD2) receptor antagonist with a Kd value of 1.14 nM for CRTH2/DP2. It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays (IC₅₀ = 0.44 nM) and to inhibit PGD2-induced cytokine release in human Th2 cells (IC₅₀s = 2.56 and 1.4 nM for IL-5 and IL-13, respectively). This compound has undergone testing in a phase II clinical study in uncontrolled allergic asthma.
Fevipiprant is a prostaglandin D2 (PGD2) receptor antagonist with a Kd value of 1.14 nM for CRTH2/DP2. It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays (IC₅₀ = 0.44 nM) and to inhibit PGD2-induced cytokine release in human Th2 cells (IC₅₀s = 2.56 and 1.4 nM for IL-5 and IL-13, respectively). This compound has undergone testing in a phase II clinical study in uncontrolled allergic asthma.
Alternate Name/Synonyms: 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid; NVP-QAW039; QAW039
Appearance: White to of-white solid
Formulation: N/A
CAS Number: 872365-14-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₉H₁₇F₃N₂O₄S
Molecular Weight: 426.41
Cell-Permeable?: yes
Purity: ≥98% by HPLC
Solubilities: DMSO
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A prostaglandin D2 (PGD2) receptor antagonist
MDL Number: N/A
PubChem CID: 23582412
SMILES: CC1=C(C2=C(N1CC3=C(C=C(C=C3)S(=O)(=O)C)C(F)(F)F)N=CC=C2)CC(=O)O
InChi: InChI=1S/C19H17F3N2O4S/c1-11-15(9-17(25)26)14-4-3-7-23-18(14)24(11)10-12-5-6-13(29(2,27)28)8-16(12)19(20,21)22/h3-8H,9-10H2,1-2H3,(H,25,26)
InChi Key: GFPPXZDRVCSVNR-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |