Fexaramine | B1156

Fexaramine is a potent, selective farnesoid X receptor (FXR) agonist (EC₅₀ = 25 nM). It displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors. Fexaramine also demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids .

Fexaramine is a potent, selective farnesoid X receptor (FXR) agonist (EC₅₀ = 25 nM). It displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors. Fexaramine also demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids .

B1156 | Fexaramine DataSheet

Alternate Name/Synonyms: Methyl (E)-3-(3-(N-((4'-(dimethylamino)-[1,1'-biphenyl]-4-yl)methyl)cyclohexanecarboxamido)phenyl)acrylate

Appearance: Yellow solid

Formulation: N/A

CAS Number: 574013-66-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₃₆N₂O₃

Molecular Weight: 498.65

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: a potent, selective farnesoid X receptor (FXR) agonist

MDL Number: MFCD09971007

PubChem CID: 5326713

SMILES: CN(C)C1=CC=C(C=C1)C2=CC=C(C=C2)CN(C3=CC=CC(=C3)C=CC(=O)OC)C(=O)C4CCCCC4

InChi: InChI=1S/C32H36N2O3/c1-33(2)29-19-17-27(18-20-29)26-15-12-25(13-16-26)23-34(32(36)28-9-5-4-6-10-28)30-11-7-8-24(22-30)14-21-31(35)37-3/h7-8,11-22,28H,4-6,9-10,23H2,1-3H3/b21-14+

InChi Key: VLQTUNDJHLEFEQ-KGENOOAVSA-N