FGF-basic 147, Bovine Recombinant | P1591

FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in 5 different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.

P1591 | FGF-basic 147, Bovine Recombinant DataSheet

Biomolecule/Target :

Synonyms: HBGH-2, HBGF-2, Prostatropin, FGF-2, FGB-b.

Alternates names: HBGH-2, HBGF-2, Prostatropin, FGF-2, FGB-b.

Taglines: A growth factor involved in angiogenesis, wound healing and embryonic development

NCBI Gene ID #: 281161

NCBI Gene Symbol: FGF2

Gene Source: Bovine

Accession #: P03969

Recombinant: TRUE

Source: E. coli

Purity by SDS-PAGE: >97%

Assay:

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Unit Definition:

Molecular Weight: 16.5 kDa (147 aa)

Concentration:

Appearance: Lyophilized

Physical form description: Lyophilized from a 0.2um filtered concentrated solution in PBS, pH 7.4.

Reconstitution Instructions: It is recommended to reconstitute the Fibroblast Growth Factor-basic (147 a.a.) in sterile PBS not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

Amino acid sequence: MPALPEDGGS GAFPPGHFKD PKRLYCKNGG FFLRIHPDGR VDGVREKSDP HIKLQLQAEE RGVVSIKGVC ANRYLAMKED GRLLASKCVT DECFFFERLE SNNYNTYRSR KYSSWYVALK RTGQYKLGPK TGPGQKAILF LPMSAKS.

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans