FGF2 Antibody [APC00103G]

FGF2 Antibody [APC00103G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FGF2 antibody is generated from a rabbit immunized with a recombinant protein.

Cellular Localisation: Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER) /Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531) . Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063) . Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063)

Molecular Weight: 30770

Clone: Polyclonal

Gene Name: FGF2

Gene ID: 2247

Function: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044) . Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677) . Binds to integrin ITGAV:ITGB3 (PubMed:28302677) . Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677) . Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3964259, PubMed:3732516) . Can induce angiogenesis (PubMed:23469107, PubMed:28302677) . Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879) .

Summary: Tissue Location: Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Fibroblast growth factor 2, FGF-2, Basic fibroblast growth factor, bFGF, Heparin-binding growth factor 2, HBGF-2, FGF2, FGFB