FGFR2/CD332 Mouse monoclonal Antibody | MB9029

FGFR2/CD332 Mouse monoclonal Antibody | MB9029 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, mouse

Application: WB ICC IHC

Application Range: WB: 1:500 IHC/ICC: 1:100-1:200

Background: Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 has two naturally occurring isoforms FGFR2IIIb and FGFR2IIIc, created by splicing of the third immunoglobulin-like domain. FGFR2IIIb is predominantly found in ectoderm derived tissues and endothelial organ lining, i.e. skin and internal organs. FGFR2 has important roles in embryonic development and tissue repair, especially bone and blood vessels. Like the other members of the Fibroblast growth factor receptor family, these receptors signal by binding to their ligand and dimerisation (pairing of receptors), which causes the tyrosine kinase domains to initiate a cascade of intracellular signals. As mentioned, FGFR2 mutations are associated with craniosynostosis syndromes, which are skull malformations caused by premature fusion of cranial sutures and other disease features according to the mutation itself.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: This Antibody detects endogenous levels of FGFR2 and does not cross-react with related proteins.

Molecular Weight: Predicted band size:92 KDa Observed band size:100, 150 KDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Fibroblast growth factor receptor 2; FGFR-2; K-sam; KGFR; Keratinocyte growth factor receptor; CD332; FGFR2; BEK; KGFR; KSAM

Immunogen: This Antibody is produced by immunizing mice with a recombinant protein corresponding to a region of FGFR2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein A affinity purified

Pathway: