FGFR4 polyclonal Antibody | BS60719

FGFR4 polyclonal Antibody | BS60719 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor or FGFR-1, the Bek receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human FGFR-4, unlike the other FGFR genes, is alternatively spliced to produce only one isoform. It is expressed in fetal adrenal, lung, kidney, liver, pancreas, intestine, striated muscle and spleen tissues. FGFR-4 is also overexpressed in breast cancers and, subsequently, is a potential target for drug therapy.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: FGFR4 polyclonal Antibody detects endogenous levels of FGFR4 protein.

Molecular Weight: ~ 88 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Fibroblast growth factor receptor 4; FGFR-4; CD334; FGFR4; JTK2; TKF

Immunogen: A synthetic peptide corresponding to residues in Human FGFR4

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Mitochondrial Control of Apoptosis,