Description
FGR Antibody | 18-481 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FGR (NP_005239.1) .
Research Area: Cancer, Immunology, Signal Transduction
Tested Application: WB, IHC
Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Specificiy: N/A
Positive Control 1: HL-60
Positive Control 2: U-937
Positive Control 3: Raji
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 53kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, SRC2, Oncogene FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene is a member of the Src family of protein tyrosine kinases (PTKs) . The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.