Fibrinogen, Biotin conjugated | IMS06-038-312

Fibrinogen, Biotin conjugated | IMS06-038-312 | Gentaur UK, US & Europe Distribution

Immunogen: Purified, full length native fibrinogen UniProt: Q9UE34

Host: Chicken

Conjugation: Biotin

Clonality: Polyclonal

Isotype: N/A

Purity: Immunogen affinity purified IgY in 0.15M sodium chloride, 0.02M sodium phosphate, 0.1% sodium azide., pH 7.2.

Format: Liquid

Tested Application: immunodifusion (ID), Western blot (WB)

Related Products: IMS09-038-335 Anti-Fibrinogen | labelled with fluorescien, chicken antibodies

Recommended Dilutions: 1 : 5000 (WB)

Molecular weight: 75 kDa

Confirmed Reactivity: Human

Predicted Reactivity: Bovine, Mouse, Porcine, Rabbit, Rat

Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Additional Information: Only one precipitation arc in immunodiffusion and immunoelectrophoresis against normal human plasma or human fibrinogen

Background: Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N-terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel et al. 2000; Rapold et al. 1989) .

Reconstitution: N/A

Storage: Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Cardiovascular

Research Area: Proteomics