CO4 | Complement component C4, Biotin conjugated | IMS06-032-304

CO4 | Complement component C4, Biotin conjugated | IMS06-032-304 | Gentaur UK, US & Europe Distribution

Immunogen: full length native protein UniProt:P0C0L4 purified from human plasma

Host: Chicken

Conjugation: Biotin

Clonality: Polyclonal

Isotype: N/A

Purity: Immunogen affinity purified IgY in 0.15M sodium chloride, 0.02M sodium phosphate, 0.1% sodium azide., pH 7.2.

Format: Liquid

Tested Application: Western blot (WB)

Related Products: IMS02-032-303 | Anti-Complement component C4, chicken antibodiesIMS01-031-305 | Anti-Complement component C4c, chicken antibodiesIMS01-066-309 | Anti-Complement factor H, chicken antibodies

Recommended Dilutions: Use at an assay dependent dilution (WB)

Molecular weight: 193 kDa

Confirmed Reactivity: Human

Predicted Reactivity: Human

Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Additional Information: Prior to conjugation: Only one precipitin arc in immunodiffusion against normal human serum or human C4, Only one precipitin arc in immunoelectrophoresis against normal human serum or human C4, Specific against human C4 alpha and beta chains in electroblotting when tested against normal human serum

Background: Complement component C4 consists of three polypeptide chains (alpha, molecular weight 95 kDa; beta, molecular weight 75 kDa and gamma, molecular weight 33 kDa) and is usually present in serum at 200-600 mg/L. It is a protein of the classical complement pathway. When activated by C1s, peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.

Reconstitution: N/A

Storage: Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Immunology

Research Area: Immunology