CO4 | Complement component C4 | IMS02-032-303

CO4 | Complement component C4 | IMS02-032-303 | Gentaur UK, US & Europe Distribution

Immunogen: full length native protein P0C0L4 purified from human plasma

Host: Chicken

Conjugation: N/A

Clonality: Polyclonal

Isotype: N/A

Purity: Immunogen affinity purified IgY in 0.15M sodium chloride, 0.02M sodium phosphate, 0.1% sodium azide., pH 7.2.

Format: Liquid

Tested Application: Affinity purified IgY

Related Products: IMS06-032-304 | anti-Complement component C4, biotinylatedIMS01-031-305 | anti-Complement component C4cIMS01-066-309 | anti-Complement factor HSecondary antibodies

Recommended Dilutions: 1 : 2000 (ELISA), 1 : 1000 (WB)

Molecular weight: 193 kDa

Confirmed Reactivity: Human

Predicted Reactivity: Human

Not reactive in: No confirmed exceptions from predicted reactivity are currently known

Additional Information: Only one precipitin arc in immunodiffusion against normal human serum or human complement component C4. Only one precipitin arc in immunoelectrophoresis against normal human serum or human complement component C4.ELISA has been performed on C4 deposition using human and mouse serum.

Background: Complement component C4 consists of three polypeptide chains (alpha, molecular weight 95 kDa; beta, molecular weight 75 kDa and gamma, molecular weight 33 kDa) and is usually present in serum at 200-600 mg/L. It is a protein of the classical complement pathway. When activated by C1s, peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.

Reconstitution: N/A

Storage: Store at 4°C; make aliquots to avoid working with a stock. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

TAIR Nnumbre: N/A

Category: Immunology

Research Area: Immunology