Filgotinib | 2871

Filgotinib (GLPG0634) is a potent and selective JAK1 inhibitor; displays >30-fold selectivity for JAk1 over JAK2. GLPG0634 dose-dependently inhibits Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.

Filgotinib (GLPG0634) is a potent and selective JAK1 inhibitor; displays >30-fold selectivity for JAk1 over JAK2. GLPG0634 dose-dependently inhibits Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.

2871 | Filgotinib DataSheet

Alternate Name/Synonyms: N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide; GLPG0634

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1206161-97-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₃N₅O₃S

Molecular Weight: 425.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective JAK1 inhibitor

MDL Number: N/A

PubChem CID: 49831257

SMILES: C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5

InChi: InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)

InChi Key: RIJLVEAXPNLDTC-UHFFFAOYSA-N