Filipin III | 2744

Filipin III is a polyene macrolide antibiotic isolated from Streptomyces filipinensis. It may be used in a double staining procedure for the detection of lipoproteins. Binds specifically to cholesterol forming a fluorescent complex which may be used for staining. Filipin III disrupts the lipid raft/caveolae endocytosis pathway. Prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.

Filipin III is a polyene macrolide antibiotic isolated from Streptomyces filipinensis. It may be used in a double staining procedure for the detection of lipoproteins. Binds specifically to cholesterol forming a fluorescent complex which may be used for staining. Filipin III disrupts the lipid raft/caveolae endocytosis pathway. Prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release.

2744 | Filipin III DataSheet

Alternate Name/Synonyms: 4S,​6S,​8S,​10R,​12R,​14R,​16S,​27S-​octahydroxy-​3R-​(1R-​hydroxy-​hexyl)17,​28R-​dimethyl-​oxacyclooctacosa-​17E,​19E,​21E,​21E,​23E,​25E-​pentaen-​2-​one

Appearance: Tan solid

Formulation: N/A

CAS Number: 480-49-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₅H₅₈O₁₁

Molecular Weight: 654.8

Cell-Permeable?: Yes

Purity: ≥85% by HPLC

Solubilities: DMSO (5 mg/ml) or EtOH (2 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A useful cholesterol probe

MDL Number: MFCD00466923

PubChem CID: 6433194

SMILES: CCCCCC(C1C(CC(CC(CC(CC(CC(CC(C(=CC=CC=CC=CC=CC(C(OC1=O)C)O)C)O)O)O)O)O)O)O)O

InChi: InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1

InChi Key: IMQSIXYSKPIGPD-YQRUMEKGSA-N