Fingolimod (FTY-720A, FTY720) | 1618

FTY720 can be phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). IC₅₀ of (S)- and (R)- FTY720-phosphate on lymphocyte migration toward 10 nM of S1P are 0.137 nM and 10.98 nM respectively. The IC₅₀ values to cell lines MCF-7 is 6.8±0.6 µM.

Fingolimod (FTY720) is a sphingosine 1-phosphate receptor modulator. An immunomodulating drug.

1618 | Fingolimod (FTY-720A, FTY720) DataSheet

Alternate Name/Synonyms: FTY-720A, FTY720

Appearance: White solid

Formulation: N/A

CAS Number: 162359-56-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₃₃NO₂.HCl

Molecular Weight: 343.93

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (100 mg/ml) of EtOH (100 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A novel immune modulator

MDL Number: MFCD00939512

PubChem CID: 107969

SMILES: CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl

InChi: InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H

InChi Key: SWZTYAVBMYWFGS-UHFFFAOYSA-N