Description
FITC Anti-Human CD197/CCR7 Antibody[G043H7] | E-AB-F1159C | Gentaur UK, US & Europe Distribution
Category: Flowcytometry Antibody
Synonyms: CMKBR7, EBI1, EVI1,CCR-7,CDw197
Swissprot Code: P32248
Application: FCM
Reactivity: Human
Host: Mouse
Isotype: Mouse IgG1, κ
Research Areas: Cancer, Immunology, Signal transduction
Backgroun: CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Nave T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. Product Details
Concentration: N/A
Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Immunogen: N/A
Buffer: PBS with 0.05% Proclin300, 1% BSA
Purification Method: N/A
Dilution: N/A
Clone: G043H7
Conjugation: FITC
Moleculair Weight(Calculated): N/A
Moleculair Weight(Observed): N/A