552
FITC-conjugated Sheep Anti-Human Apolipoprotein (a) | ABMC-F02
- SKU:
- 552-F02-GEN
- Availability:
- IN STOCK
Description
FITC-conjugated Sheep Anti-Human Apolipoprotein (a) |F02
| Host Species: | Sheep |
| Concentration: | 1 mg/ml (OD 1.35 / 280 nm) |
| Antigen: | Human Apolipoprotein (a) |
| Purification: | Affinity purified |
| Buffer: | 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2 |
| Specificity | Specifically binds to human apo (a). Molar F/P ratio is 5.7. The investigator should determine working dilutions. |
| Use: | The antibody can be used for detection of human albumin in plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation. |
| Storage: | -20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing. |
| Form: | Freeze dried powder |
| Stabilizer: | 5 mg / ml Bovine Serum Albumin. |
| Reconstitution and Storage: | Freeze-dried product should be stored refrigerated until opened. After opening, restore to suggested ml volume with distilled water. If it is not completely clear after standing for 1-2 hours at room temperature, centrifuge the product. It is stable for several weeks at 4°C as an undiluted liquid. Do not use for more than one day after dilution. For extended storage after reconstitution, we suggest aliquot to avoid repeated freezing and thawing; or the addition of an equal volume of glycerol to make a final glycerol concentration of 50%, followed by storage at -20°C. The concentration of protein and buffer salts will decrease to one-half of the original after the addition of glycerol. |
*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.
IMPORTANCE
The Lipoprotein (a) [Lp(a)] structure is similar to that of low density lipoprotein (LDL), regarding size and lipid composition of the particles and the presence of apolipoprotein B-100 (apo B-100). In addition to apo B-100, Lp(a) has a second protein, apolipoprotein (a) [apo (a)], which the molecular weight of that glycoprotein varies widely from 400 to 700 kDa. (Maranhão et al., 2013)
Previous research has shown that apo (a) has a similar structure with plasminogen and contains a serine protease domain and two types of plasminogen-like kringle domains. (McLean et al., 1987) The plasma concentration of human lipoprotein[a], Lp[a], is highly correlated with coronary artery disease. (Gaubatz et al., 1990)
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