FK-506 | 1563

A potent immunosuppresant and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T-lymphocytes. It interacts with its FK506-binding protein-12 (FKBP-12), leading to increase in the release of sarcoplamic reticulum-derived calcium. FK506 and rapamycin, but not cytosporin inhibit aldosterone-stimulated sodium transport in A6 cells.

FK-506 is a A potent immunosuppresant and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T-lymphocytes. It interacts with its FK506-binding protein-12 (FKBP-12), leading to increase in the release of sarcoplamic reticulum-derived calcium.

1563 | FK-506 DataSheet

Alternate Name/Synonyms: Tacrolimus

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 104987-11-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₄H₆₉NO₁₂

Molecular Weight: 804.02

Cell-Permeable?: No

Purity: ≥98%

Solubilities: DMSO (20 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent immunosuppresant

MDL Number: MFCD11045918

PubChem CID: 445643

SMILES: CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC

InChi: InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

InChi Key: QJJXYPPXXYFBGM-LFZNUXCKSA-N