FK-866 | 1914

Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC₅₀ = ~1 nM).

FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators.

1914 | FK-866 DataSheet

Alternate Name/Synonyms: N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 658084-64-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₉N₃O₂

Molecular Weight: 391.51

Cell-Permeable?: Yes

Purity: ≥98% by NMR

Solubilities: DMSO (>30 mg/ml) and Ethanol

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT)

MDL Number: N/A

PubChem CID: 6914657

SMILES: C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3

InChi: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13- 17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14, 16-18H2,(H,26,28)/b12-11+

InChi Key: KPBNHDGDUADAGP-VAWYXSNFSA-N