FKBP8 Antibody (Center) [APR05693G]

FKBP8 Antibody (Center) [APR05693G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FKBP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-226 amino acids from the Central region of human FKBP8.

Cellular Localisation: Mitochondrion. Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side [Isoform 3]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side

Molecular Weight: 44562

Clone: Polyclonal

Gene Name: FKBP8

Gene ID: 23770

Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.

Summary: Tissue Location: Widely expressed. Highest levels seen in the brain. Highly abundant in the retina.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Peptidyl-prolyl cis-trans isomerase FKBP8, PPIase FKBP8, 38 kDa FK506-binding protein, 38 kDa FKBP, FKBP-38, hFKBP38, FK506-binding protein 8, FKBP-8, FKBPR38, Rotamase, FKBP8, FKBP38