FKHR/FoxO1 (phospho-S256) polyclonal Antibody | BS4711

FKHR/FoxO1 (phospho-S256) polyclonal Antibody | BS4711 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC IF

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background: FOXO1A (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein which is a member of a subfamily of the forkhead homeotic gene family of transcription factors. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Chromosomal aberrations involving FOXO1A are a cause of rhabdomyosarcoma 2 (RMS2) ; also known as alveolar rhabdomyosarcoma.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-FoxO1 (S256) polyclonal Antibody detects endogenous levels of FoxO1 protein only when phosphorylated at Ser256.

Molecular Weight: ~ 70 to 82 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; FOXO1; FKHR; FOXO1A

Immunogen: Synthetic phosphopeptide derived from human FKHR around the phosphorylation site of Serine 256.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Insulin &Glucose Signaling,Cell Cycle Control G1 S Checkpoint,