FLT3 monoclonal Antibody | MB63307

FLT3 monoclonal Antibody | MB63307 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse

Application: WB

Application Range: WB 1:500

Background: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jul 2008]

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: fms related tyrosine kinase 3

Molecular Weight: 112.7 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: CD135; FLK-2; FLK2; STK1

Immunogen: Human recombinant protein fragment corresponding to amino acids 169-444 of human FLT3 (NP_004110) produced in E.coli.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A