FNDC4, human/mouse recombinant | 7573

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes.

7573 | FNDC4 human/mouse recombinant DataSheet

Biomolecule/Target: FNDC4

Synonyms: Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1

Alternates names: Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1

Taglines: An ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin.

NCBI Gene ID #: 2252

NCBI Gene Symbol: HBGF-7

Gene Source: Human/Mouse

Accession #: P21781

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: ~16.0 kDa. (Extracellular domain, human (aa 45-167) / mouse (aa 41-163)) is untagged. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey.

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized in PBS.

Reconstitution Instructions: Reconstitute with 100 l sterile distilled water.

Amino acid sequence: N/A