BW
FOLH1 monoclonal Antibody | MB63317
- SKU:
- BW-MB63317
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- Usually ships in 5 working days
Description
FOLH1 monoclonal Antibody | MB63317 | Gentaur UK, US & Europe Distribution
Host: Mouse
Reactivity: Human, Mouse
Application: ELISA, WB
Application Range: WB 1:1000~2000
Background: This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq]
Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Specificity: folate hydrolase (prostate-specific membrane antigen) 1
Molecular Weight: 84.2 kDa (Predicted)
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA
Immunogen: Full length human recombinant protein of human FOLH1 (NP_004667) produced in HEK293T cell.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Pathway: N/A