26
Follistatin, human recombinant | 4708
- SKU:
- 26-4708-GEN
- Availability:
- Usually shipped in 5 working days
Description
Follistatin belongs to a group of structurally-diverse diffusible proteins that binds to TGF- ligands and inhibit their activity by hindering access to signaling receptors. This naturally occurring antagonist binds to Activin, BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids including 36 cysteine residues.
4708 | Follistatin human recombinant DataSheet
Biomolecule/Target: N/A
Synonyms: FST, FS, Activin-binding protein
Alternates names: NOG
Taglines: An autocrine glycoprotein involved in binding and bioneutralization of members of the TGF- superfamily
NCBI Gene ID #: 9241
NCBI Gene Symbol: NOG
Gene Source: Human
Accession #: Q13253
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: HPLC
Endotoxin Level: <0.1 ng/g
Activity (Specifications/test method): N/A
Biological activity: Determined by its ability to inhibit 5 ng/ml of BMP-4-induced alkaline phosphatase production by ATDC chondrogenic cells. The expected ED for the effect is 0.05-0.08 µg/ml of Noggin
Results: 0.1-0.4 µg/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 23.1 kDa
Concentration: N/A
Appearance: Lyophilized protein
Physical form description: Sterile filtered and lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 75 mM NaCl
Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1 to 1.0 mg/ml. Note: Due to solubility reasons the protein should be kept at low pH. This solution can then be diluted into other aqueous buffers
Amino acid sequence: N/A