Fosaprepitant | 9529

Fosaprepitant is a prodrug of Aprepitant (Cat. No. 9531) that acts as a selective, high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. After biologically activated to Aprepitant, it acts as an antiemetic agent.

Fosaprepitant is a prodrug of Aprepitant (Cat. No. 9531) that acts as a selective, high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. After biologically activated to Aprepitant, it acts as an antiemetic agent.

9529 | Fosaprepitant DataSheet

Alternate Name/Synonyms: P-[3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonic Acid; L 758298

Appearance: White solid

Formulation: N/A

CAS Number: 172673-20-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₂F₇N₄O₆P

Molecular Weight: 614.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A prodrug of Aprepitant that acts as a selective, high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors

MDL Number: N/A

PubChem CID: 219090

SMILES: CC(C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC2C(N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F

InChi: InChI=1S/C23H22F7N4O6P/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38)/t12-,19+,20-/m1/s1

InChi Key: BARDROPHSZEBKC-OITMNORJSA-N