Fostriecin sodium | B1241

Fostriecin is a potent inhibitor of the serine/threonine protein phosphatases PP2A and PP4 with IC₅₀ value of 3.2 and 3 nM, respectively. It also displays weak inhibition of topoisomerase II having IC₅₀ of 40 μM and PP1 with IC₅₀ of 131 μM. Fostriecin has antitumor activity against a wide spectrum of tumor cells in vitro and excellent activity against P388 and L1210 leukemias in vivo.

Fostriecin is a potent inhibitor of the serine/threonine protein phosphatases PP2A and PP4 with IC₅₀ value of 3.2 and 3 nM, respectively. It also displays weak inhibition of topoisomerase II having IC₅₀ of 40 μM and PP1 with IC₅₀ of 131 μM. Fostriecin has antitumor activity against a wide spectrum of tumor cells in vitro and excellent activity against P388 and L1210 leukemias in vivo.

B1241 | Fostriecin sodium DataSheet

Alternate Name/Synonyms: (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt

Appearance: Coloreless solid

Formulation: N/A

CAS Number: 87860-39-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: Yes

Molecular Formula: C₁₉H₂₆O₉PNa

Molecular Weight: 452.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: Water(>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of the serine/threonine protein phosphatases PP2A and PP4

MDL Number: N/A

PubChem CID: 16759606

SMILES: CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]

InChi: InChI=1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1/b3-2-,6-4+,8-5-,12-11+;/t15-,16+,17+,19+;/m0./s1

InChi Key: XBUIKNRVGYFSHL-IAVQPKKASA-M