FOXO4 polyclonal Antibody | BS90532

FOXO4 polyclonal Antibody | BS90532 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC

Application Range: WB:1:1,000-1:2,000 IHC:1:50-1:200

Background: FKHR (for forkhead in rhabdomyosarcoma), FKHRL1, and AFX1 are members of a subfamily of the forkhead family of transcription factors. AFX1, also known as FoxO4, is expressed in a wide variety of tissues and, like other FKHR proteins, AFX1 contains a single forkhead domain and serine-proline-rich region, which mediate DNA binding. AFX1-mediated transcriptional activation is regulated by the serine/threonine kinase Akt1, which phosphorylates AFX1 and in turn, sequesters AFX1 in the cytosol, thereby blocking nuclear localization and DNA binding. Genetic mutations in FKHR genes, including the t (2;13) and t (1;3) translocations, are commonly found in alveolar rhabdomyosarcomas. Additionally, the t (x;11) translocation of the AFX1 gene, which involves the fusion of a serine-proline-rich sequence of AFX1 to the carboxy terminus of a truncated MLL, results in acute lymphocytic leukemia.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: FOXO4 polyclonal Antibody detects endogenous levels of FOXO4 protein.

Molecular Weight: 54/48 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: FOXO4, AFX, AFX1, Afxh, ALL1-fused gene from X chromosome, Fork head domain transcription factor AFX1, Forkhead box O4, Forkhead box protein O4, FOXO 4, Foxo4, FOXO4, MGC117660, MGC120490, Mixed lineage leukemia, translocated to, 7, MLLT7, Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog, Drosophila) ; translocated to, 7, Myeloid/lymphoid or mixed lineage leukemia, translocated to, 7, RGD1561201,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: