FPS-ZM1 | B1933

FPS-ZM1 is a high-affinity, brain-permeable, RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo. In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage. It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling.

FPS-ZM1 is a high-affinity, brain-permeable, RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Aβ via binding to the V domain of RAGE and can block multiple mechanisms of Aβ40- and Aβ42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo.

B1933 | FPS-ZM1 DataSheet

Alternate Name/Synonyms: 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide

Appearance: White solid

Formulation: N/A

CAS Number: 945714-67-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₂ClNO

Molecular Weight: 327.85

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 30 mg/ml) or EtOH (~25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A high-affinity RAGE (Receptor for Advanced Glycation End products) receptor antagonist

MDL Number: N/A

PubChem CID: 24752728

SMILES: C1CCC(CC1)N(CC2=CC=CC=C2)C(=O)C3=CC=C(C=C3)Cl

InChi: InChI=1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2

InChi Key: XDFKWGIBQMHSOH-UHFFFAOYSA-N