FRK, Active | 7765

FRK (fyn-related kinase) or Rak is a nuclear tyrosine kinase and member of the Src sub-family. Restricted expression of FRK is detected in a broad range of cell lines with highest levels in epithelial cells. Increased expression of FRK has been shown in breast and renal cell carcinoma cell lines. In addition the retinoblastoma tumor susceptibility gene product pRb associates with FRK in vitro and in vivo (1). Overexpression of FRK in -cells from the pancreas increases the susceptibility of these cells to -cell-toxic events (hallmark of Type I diabetes)(2).

7765 | FRK Active DataSheet

Biomolecule/Target: N/A

Synonyms: FRK, fyn-related kinase

Alternates names: FRK, fyn-related kinase, FYN-related kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5

Taglines: Functions during G1 and S phase of the cell cycle and suppresses growth

NCBI Gene ID #: 2253

NCBI Gene Symbol: FGF-8

Gene Source: N/A

Accession #: P55075

Recombinant: Yes

Source: Baculovirus (Sf9 insect cells)

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): The specific activity of FRK was determined to be 997 nmol /min/mg as per activity assay protocol.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 60.0 kDa

Concentration: 0.1mg/ml

Appearance: Liquid

Physical form description: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Reconstitution Instructions: N/A

Amino acid sequence: N/A