Description
Fruquintinib (HMPL-013) is a potent and selective vascular endothelial growth factor receptors1/2/3 (VEGFR 1/2/3) inhibitor with IC₅₀s of 33, 0.35, and 35 nM, respectively. It only weakly inhibits RET, FGFR-1 and c-kit kinases.
Fruquintinib (HMPL-013) is a potent and selective vascular endothelial growth factor receptors1/2/3 (VEGFR 1/2/3) inhibitor with IC₅₀s of 33, 0.35, and 35 nM, respectively. It only weakly inhibits RET, FGFR-1 and c-kit kinases.
B1979 | Fruquintinib DataSheet
Alternate Name/Synonyms: (Z)-6-((6,7-dimethoxyquinazolin-4-yl)oxy)-N,2-dimethylbenzofuran-3-carbimidic acid; HMPL-013
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1194506-26-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₁H₁₉N₃O₅
Molecular Weight: 393.39
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>6 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent VEGFR inhibitor
MDL Number: N/A
PubChem CID: 44480399
SMILES: CC1=C(C2=C(O1)C=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(=O)NC
InChi: InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)
InChi Key: BALLNEJQLSTPIO-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |