Fruquintinib | B1979

Fruquintinib (HMPL-013) is a potent and selective vascular endothelial growth factor receptors1/2/3 (VEGFR 1/2/3) inhibitor with IC₅₀s of 33, 0.35, and 35 nM, respectively. It only weakly inhibits RET, FGFR-1 and c-kit kinases.

Fruquintinib (HMPL-013) is a potent and selective vascular endothelial growth factor receptors1/2/3 (VEGFR 1/2/3) inhibitor with IC₅₀s of 33, 0.35, and 35 nM, respectively. It only weakly inhibits RET, FGFR-1 and c-kit kinases.

B1979 | Fruquintinib DataSheet

Alternate Name/Synonyms: (Z)-6-((6,7-dimethoxyquinazolin-4-yl)oxy)-N,2-dimethylbenzofuran-3-carbimidic acid; HMPL-013

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1194506-26-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₉N₃O₅

Molecular Weight: 393.39

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>6 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent VEGFR inhibitor

MDL Number: N/A

PubChem CID: 44480399

SMILES: CC1=C(C2=C(O1)C=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(=O)NC

InChi: InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)

InChi Key: BALLNEJQLSTPIO-UHFFFAOYSA-N