FSHR polyclonal Antibody | BS5724

FSHR polyclonal Antibody | BS5724 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC ICC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200 ICC: 1:50~1:200

Background: Follicle-stimulating hormone receptor (FSHR) is a 695 amino acid G-protein coupled receptor. FSH binds to the receptor in a hand-clasp fashion via its α and β subunits. While the α subunit of FSH is involved in the binding of FSH to the receptor, the β subunit stabilizes this interaction. Linkage studies suggest that a missense mutation in the FSHR gene can cause reduced FSH binding affinity and lead to a condition known as hypergonadotropic ovarian dysgenesis (ODG) . In males however, this mutation does not appear to have a detrimental affect on fertility. It is believed that a mutation in the FSHR gene is also associated with ovarian hyperstimulation syndrome; a condition characterized by the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: FSHR polyclonal Antibody detects endogenous levels of FSHR protein.

Molecular Weight: ~ 78 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor; LGR1

Immunogen: Synthetic peptide, corresponding to amino acids 330-375 of Human FSHR.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: