Description
Fulvestrant is a high affinity estrogen receptor antagonist (IC₅₀ = 0.29 nM), that works by down-regulating and degrading the estrogen receptor, ERα. Reported to lack any partial agonist activity.
Fulvestrant is a high affinity estrogen receptor antagonist (IC₅₀ = 0.29 nM), that works by down-regulating and degrading the estrogen receptor, ERα. Reported to lack any partial agonist activity.
Alternate Name/Synonyms: (7R,8R,9S,13S,14S,17S)-13-methyl-7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol; ICI182,780
Appearance: White solid
Formulation: N/A
CAS Number: 129453-61-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₃H₄₇F₅O₃S
Molecular Weight: 606.77
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>50 mg/ml) or EtOH (>25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A high affinity estrogen receptor antagonist
MDL Number: MFCD00903953
PubChem CID: 104741
SMILES: CC12CCC3C(C1CCC2O)C(CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F
InChi: InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
InChi Key: VWUXBMIQPBEWFH-WCCTWKNTSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
Related Products
