Furamidine dihydrochloride | B2581

Furamidine dihydrochloride is a potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.

uramidine dihydrochloride is a potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.

B2581 | Furamidine dihydrochloride DataSheet

Alternate Name/Synonyms: 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride

Appearance: Yellow solid

Formulation:

CAS Number: 55368-40-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₆N₄O.2HCl

Molecular Weight: 377.27

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >15 mg/ml in Water, >15 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective PRMT1 inhibitor

MDL Number:

PubChem CID: 126437

SMILES: C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N.Cl.Cl

InChi: InChI=1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H

InChi Key: