Furin, Human Recombinant | P1658

Furin is a member of the proprotein convertase family. As a cellular protease, Furin processes various latent precursor proteins into their biologically active products by cleaving at the RX(K/R)R consensus motif. Some of its substrates are various growth factors, serum proteins, proteases of the blood-clotting and complement systems, matrix metalloproteinases, receptors, viral-envelope glycoproteins, and bacterial exotoxins. Furin play an essential role in embryogenesis and homeostasis and is implicated in various pathologies such as cancer, neurodegenerative diseases and anthrax. A Furin cleavage site (PRRAR) in the SARS-CoV-2 spike protein is considered a key contributor to COVID-19 pathogenesis. The purified human recombinant Furin is a truncated soluble protein (27-574 aa) that lacks the transmembrane domain.

P1658 | Furin, Human Recombinant DataSheet

Biomolecule/Target :

Synonyms: Furin,Recombinant Furin,Human Recombinant Furin

Alternates names: Furin,Recombinant Furin,Human Recombinant Furin

Taglines: A member of the proprotein convertase family.

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Human

Accession #:

Recombinant: FALSE

Source: Insect Cells (sf9)

Purity by SDS-PAGE: ≥ 95% by SDS-PAGE

Assay:

Purity:

Assay #2:

Endotoxin Level: N/A

Activity (Specifications/test method): > 20 mU/mg

Biological activity:

Results:

Binding Capacity:

Unit Definition: One unit of Furin is the amount of enzymes that cleaves a fluorescent peptidyl substrate and liberates 1 umol AMC per minute at pH 7.5, 25 ºC.

Molecular Weight: 62 kDa (contains His tag at the C-terminus)

Concentration: Lot specific

Appearance: Liquid protein

Physical form description: Liquid

Reconstitution Instructions:

Amino acid sequence:

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans