26
Furin, Human Recombinant | P1658
- SKU:
- 26-P1658-GEN
- Availability:
- Usually shipped in 5 working days
Description
Furin is a member of the proprotein convertase family. As a cellular protease, Furin processes various latent precursor proteins into their biologically active products by cleaving at the RX(K/R)R consensus motif. Some of its substrates are various growth factors, serum proteins, proteases of the blood-clotting and complement systems, matrix metalloproteinases, receptors, viral-envelope glycoproteins, and bacterial exotoxins. Furin play an essential role in embryogenesis and homeostasis and is implicated in various pathologies such as cancer, neurodegenerative diseases and anthrax. A Furin cleavage site (PRRAR) in the SARS-CoV-2 spike protein is considered a key contributor to COVID-19 pathogenesis. The purified human recombinant Furin is a truncated soluble protein (27-574 aa) that lacks the transmembrane domain.
P1658 | Furin, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Furin,Recombinant Furin,Human Recombinant Furin
Alternates names: Furin,Recombinant Furin,Human Recombinant Furin
Taglines: A member of the proprotein convertase family.
NCBI Gene ID #:
NCBI Gene Symbol:
Gene Source: Human
Accession #:
Recombinant: FALSE
Source: Insect Cells (sf9)
Purity by SDS-PAGE: ≥ 95% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level: N/A
Activity (Specifications/test method): > 20 mU/mg
Biological activity:
Results:
Binding Capacity:
Unit Definition: One unit of Furin is the amount of enzymes that cleaves a fluorescent peptidyl substrate and liberates 1 umol AMC per minute at pH 7.5, 25 ºC.
Molecular Weight: 62 kDa (contains His tag at the C-terminus)
Concentration: Lot specific
Appearance: Liquid protein
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence:
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
Additional Information
Storage Temperature: |
-20°C |
Shipping: |
Gel Pack |
Shelf Life: |
12 months |