FUT6 Antibody (Center) [APR05362G]

FUT6 Antibody (Center) [APR05362G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FUT6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the Central region of human FUT6.

Cellular Localisation: Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Golgi apparatus. Secreted Note=Membrane-bound form in trans cisternae of Golgi

Molecular Weight: 41860

Clone: Polyclonal

Gene Name: FUT6 (HGNC:4017)

Gene ID: 2528

Function: [Isoform 1]: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2, 3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1, 3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe (x) ), Lewis X (Le (x) ) and non sialylated VIM2 determinants (PubMed:9451035, PubMed:1520296, PubMed:1339443, PubMed:7650030, PubMed:17604274, PubMed:9363434, PubMed:10728707) . Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants (PubMed:17604274, PubMed:1339443) . Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X (PubMed:10728707) . Does not have activity towards type 1 ( (Galbeta1- 3GlcNAc) ) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates (PubMed:1339443, PubMed:17604274, PubMed:9363434) .

Summary: Tissue Location: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Alpha- (1, 3) -fucosyltransferase 6, Fucosyltransferase 6, Fucosyltransferase VI, Fuc-TVI, FucT-VI, Galactoside 3-L-fucosyltransferase, FUT6, FCT3A