FZD4 Antibody (C-term) [APR06174G]

FZD4 Antibody (C-term) [APR06174G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This FZD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-522 amino acids from the C-terminal region of human FZD4.

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 59881

Clone: Polyclonal

Gene Name: FZD4

Gene ID: 8322

Function: Receptor for Wnt proteins (PubMed:30135577) . Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:30135577) . Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (By similarity) . In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (By similarity) . A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Summary: Tissue Location: Almost ubiquitous (PubMed:10544037) . Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney (PubMed:10544037) . Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver (PubMed:10544037)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Frizzled-4, Fz-4, hFz4, FzE4, CD344, FZD4