Description
FZD6 Polyclonal Antibody | E-AB-12926 | Gentaur UK, US & Europe Distribution
Type: Polyclonal Antibody
Synonyms: Frizzled 6 seven transmembrane spanning receptor, Frizzled drosophila homolog of 6, Frizzled family receptor 6, Frizzled homolog 6 (Drosophila), Frizzled homolog 6, Frizzled-6, Frizzled6, Fz 6, Fz-6, Fz6, FZD 6, Fzd6, FZD6, Hfz 6, hFz6, NDNC10
Application: IHC, ELISA
Reactivity: Human, Mouse
Host: Rabbit
Isotype: IgG
Reserch Areas: Stem Cells
Background: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
Concentration: 0.2 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Synthetic peptide of human FZD6
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method: Affinity purification
Dilution: IHC 1:100-1:300
Clone: N/A
Conjugation: Unconjugated
Molecular Weight(Calculated): N/A
Molecular Weight(Observed): N/A