G-749 | B2213

G-749 is a potent FLT3 kinase inhibitor that displays potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays. G-749 retains its inhibitory potency in various drug-resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection.

G-749 is a potent FLT3 kinase inhibitor that displays potent and sustained inhibition of the FLT3 wild type and mutants including FLT3-ITD, FLT3-D835Y, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays. G-749 retains its inhibitory potency in various drug-resistance milieus such as patient plasma, FLT3 ligand surge, and stromal protection.

B2213 | G-749 DataSheet

Alternate Name/Synonyms: 8-bromo-2-((1-methylpiperidin-4-yl)amino)-4-((4-phenoxyphenyl)amino)pyrido[4,3-d]pyrimidin-5(6H)-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1457983-28-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₅BrN₆O₂

Molecular Weight: 521.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent FLT3 kinase inhibitor

MDL Number: N/A

PubChem CID: 78357765

SMILES: CN1CCC(CC1)NC2=NC3=C(C(=O)NC=C3Br)C(=N2)NC4=CC=C(C=C4)OC5=CC=CC=C5

InChi: InChI=1S/C25H25BrN6O2/c1-32-13-11-17(12-14-32)29-25-30-22-20(26)15-27-24(33)21(22)23(31-25)28-16-7-9-19(10-8-16)34-18-5-3-2-4-6-18/h2-10,15,17H,11-14H2,1H3,(H,27,33)(H2,28,29,30,31)

InChi Key: SXWMIXPJPNCXQQ-UHFFFAOYSA-N