GABARAP Antibody [APR11965G]

GABARAP Antibody [APR11965G] | Gentaur UK, US & Europe Distribution

Product Category: Monoclonal Antibodies

Host: Mouse

Species Reactivity: H, M

Specificity: Purified His-tagged GABARAP protein (Fragment) was used to produced this monoclonal antibody.

Cellular Localisation: Endomembrane system {ECO:0000250|UniProtKB:P60517}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P60517}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P60517}. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P60517}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity) Localizes also to discrete punctae along the ciliary axoneme (By similarity) . {ECO:0000250|UniProtKB:P60517, ECO:0000250|UniProtKB:Q9DCD6}

Molecular Weight: 13918

Clone: Monoclonal

Gene Name: GABARAP

Gene ID: 11337

Function: Ubiquitin-like modifier that plays a role in intracellular transport of GABA (A) receptors and its interaction with the cytoskeleton (PubMed:9892355) . Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15169837, PubMed:20562859, PubMed:22948227) . Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538) . Also required for the local activition of the CUL3 (KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (PubMed:25684205) . Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (PubMed:25684205) . Involved in apoptosis (PubMed:15977068) .

Summary: Tissue Location: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.

Form: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000 WB-- 1:1000

Synonyms: Gamma-aminobutyric acid receptor-associated protein, GABA (A) receptor-associated protein, MM46, GABARAP, FLC3B