GALNT3 polyclonal Antibody | BS8280

GALNT3 polyclonal Antibody | BS8280 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB,IHC,IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200

Background: The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosaminyl) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the golgi apparatus. GalNAc-T3, also known as GALNT3, HHS or HFTC, is a 633 amino acid single-pass type II membrane protein that localizes to the golgi and contains one ricin B-type lectin domain. Expressed at high levels in kidney, testis, skin and pancreas, GalNAc-T3 uses manganese and calcium as cofactors to catalyze the first reaction in O-linked oligosaccharide biosynthesis, namely the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on a target protein. Defects in the gene encoding GalNAc-T3 are the cause of hyperphosphatemic familial tumoral calcinosis (HFTC) and hyperostosis-hyperphosphatemia syndrome (HHS) . GalNAc-T3 is overexpressed in carcinoma tissue, suggesting a role in tumor development and metastasis.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: GALNT3 polyclonal Antibody detects endogenous levels of GALNT3 protein.

Molecular Weight: ~ 73 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Polypeptide N-acetylgalactosaminyltransferase 3; Polypeptide GalNAc transferase 3; GalNAc-T3; pp-GaNTase 3; Protein-UDP acetylgalactosaminyltransferase 3; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3; GALNT3

Immunogen: Recombinant full length Human GALNT3.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: