GANT58 | 1812

Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.

GANT58 acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.

1812 | GANT58 DataSheet

Alternate Name/Synonyms: 2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75504

Appearance: Yellow solid

Formulation: N/A

CAS Number: 64048-12-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₁₆N₄S

Molecular Weight: 392.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (25 mM) or Ethanol (25 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Hedgehog (Hh) signaling pathway inhibitor

MDL Number: MFCD01103196

PubChem CID: 253078

SMILES: C1=CN=CC=C1C2=C(SC(=C2C3=CC=NC=C3)C4=CC=NC=C4)C5=CC=NC=C5

InChi: InChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H

InChi Key: USWLOKMMUTWFMD-UHFFFAOYSA-N