GANT61 | 1892

Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC₅₀ = 5 µM). GANT61 has also been shown to inhibit the in vitro proliferation of PANC1 and 22Rv1 cells which have elevated GLi11 levels and prevent the development of 22Rv1 tumors in mice.

Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC₅₀ = 5 µM). GANT61 has also been shown to inhibit the in vitro proliferation of PANC1 and 22Rv1 cells which have elevated GLi11 levels and prevent the development of 22Rv1 tumors in mice.

1892 | GANT61 DataSheet

Alternate Name/Synonyms: 2,​2'-​[[dihydro-​2-​(4-​pyridinyl)-​1,​3(2H,​4H)-​pyrimidinediyl]bis(methylene)]bis(N,​N-​dimethyl-​benzenamine); NSC 136476

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 500579-04-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₅N₅

Molecular Weight: 429.6

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>2 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Hedgehog (Hh) signaling pathway antagonist

MDL Number: MFCD14635408

PubChem CID: 421610

SMILES: CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C

InChi: InChI=1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3

InChi Key: KVQOGDQTWWCZFX-UHFFFAOYSA-N