GAS6 Antibody | 8365

GAS6 Antibody | 8365 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Rabbit: (95%)

Immunogen: GAS6 antibody was raised against a 19 amino acid peptide from near the amino terminus of human GAS6.
The immunogen is located within amino acids 60 - 110 of GAS6.

Research Area: Apoptosis, Homeostasis

Tested Application: E, WB, IHC-P

Application: GAS6 antibody can be used for the detection of GAS6 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL.
Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Specificiy: GAS6 antibody is human, mouse and rat reactive. At least four isoforms of GAS6 are known to exist; this antibody will only detect the longest isoform.

Positive Control 1: Cat. No. 1401 - Mouse Heart Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 75 kDa
Observed: 75 kDa

Validation: N/A

Isoform: N/A

Purification: GAS6 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: GAS6 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: GAS6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: Growth arrest-specific 6 protein, AXSF, AXLLG

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The growth arrest-specific 6 (GAS6) protein is a gamma-carboxyglutamic acid (Gla) -containing protein and a member of a family of plasma vitamin K-dependent proteins. GAS6 is involved in vascular homeostasis, cell proliferation, apoptosis, leukocyte migration, and platelet aggregation (1, 2) . GAS6 is the ligand for the type I transmembrane receptor tyrosine kinase receptors Tyro3, Axl, and Mer (3) . This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker (4) . Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia (2) .