GDC-0152 | B1602

GDC-0152 is a potent small molecule antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.

GDC-0152 is a potent small molecule antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.

B1602 | GDC-0152 DataSheet

Alternate Name/Synonyms: (2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide, GDC0152, GDC 0152

Appearance: Solid

Formulation: N/A

CAS Number: 873652-48-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C25H34N6O3S

Molecular Weight: 498.64

Cell-Permeable?: Yes

Purity: 98% by HPLC

Solubilities: DMSO: 99 mg/ml (198.54 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent small molecule antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3

MDL Number: NA

PubChem CID: 46940575

SMILES: CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC

InChi: 1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1

InChi Key: WZRFLSDVFPIXOV-LRQRDZAKSA-N