GDC-0349 | B1729

GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki value of 3.8 nM.

GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki value of 3.8 nM.

B1729 | GDC-0349 DataSheet

Alternate Name/Synonyms: GDC-0349; GDC0349; GDC 0349; RG7603; 1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea; (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea

Appearance: Solid

Formulation: N/A

CAS Number: 1207360-89-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₃₂N₆O₃

Molecular Weight: 452.55

Cell-Permeable?: Yes

Purity: >98%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective ATP-competitive inhibitor

MDL Number: MFCD22417087

PubChem CID: 59239165

SMILES: CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOCC5C

InChi: InChI=1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,25,26,31)/t16-/m0/s1

InChi Key: RGJOJUGRHPQXGF-INIZCTEOSA-N