GDC-0941 Dimethanesulfonate | 9618

GDC-0941 is a potent, selective, inhibitor of pan-class I PI3 kinase (PI3K), with IC₅₀ values of 3, 33, 3, 75, 1230 and 580 nM for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Displays antineoplastic activity.

GDC-0941 is a potent, selective, inhibitor of pan-class I PI3 kinase (PI3K), with IC₅₀ values of 3, 33, 3, 75, 1230 and 580 nM for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Displays antineoplastic activity.

9618 | GDC-0941 Dimethanesulfonate DataSheet

Alternate Name/Synonyms: 4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine;methanesulfonic acid; Pictilisib

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 957054-33-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₃₅N₇O₉S₄

Molecular Weight: 705.85

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent, selective, inhibitor of pan-class I PI3 kinase

MDL Number: N/A

PubChem CID: 56972143

SMILES: CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6.CS(=O)(=O)O.CS(=O)(=O)O

InChi: InChI=1S/C23H27N7O3S2.2CH4O3S/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19;2*1-5(2,3)4/h2-4,13-14H,5-12,15H2,1H3,(H,24,27);2*1H3,(H,2,3,4)

InChi Key: RFRIKACSFOTIMU-UHFFFAOYSA-N