Description
GDC-0980, a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2). It inhibits PI3Kα/β/δ/γ with IC₅₀ values of 5 nM/27 nM/7 nM/14 nM, respectively and mTOR with Ki of 17 nM. GDC-0980 is highly selective versus others PIKK family kinases. Displays anticancer activity.
GDC-0980, a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2). It inhibits PI3Kα/β/δ/γ with IC₅₀ values of 5 nM/27 nM/7 nM/14 nM, respectively and mTOR with Ki of 17 nM. GDC-0980 is highly selective versus others PIKK family kinases.
Alternate Name/Synonyms: (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one
Appearance: White solid
Formulation: N/A
CAS Number: 1032754-93-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₃₀N₈O₃S
Molecular Weight: 498.6
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent PI3K/mTOR kinase inhibitor
MDL Number: N/A
PubChem CID: 25254071
SMILES: CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)C(C)O
InChi: InChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
InChi Key: YOVVNQKCSKSHKT-HNNXBMFYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
